Dr. Karl S. Booksh is developing a fiber-optic sensor system that can detect a variety of biological molecules. The device is beneficial for spaceflight because it is able to detect infection and would be useful for wound treatment. Employing inexpensive, interchangeable parts, the sensor system will be fast, portable, and will not require lab support from the ground. The sensor system’s modular design will allow expansion to applications beyond wound healing. The technology may ultimately lead to the design of a smart bandage that can monitor wound healing.
Development of a Modular, Fiber Optic Surface Plasmon Resonance Sensor for Quantitation of Diagnostic Proteins for Healing of Burns and Wounds
Karl S. Booksh, Ph.D.
University of Delaware
- We can demonstrate our capability to construct polymer housings with pore sizes larger than proteins but smaller than cells to protect and shield the sensors surface.
- We have evidence that judicious choice and functionalization of biopolymer scaffolds can simultaneously enhance the sensor sensitivity to target analytes, while significantly reducing the degree of protein fouling on the sensor relative to SPR standard functionalized dextran hydrogel scaffolds.
- Preliminary tests in saline solution have demonstrated that the sensor system achieves physiologically relevant detection limits for two of the target biomarkers: tumor necrosis factor alpha and interleukin 6.