Previous Projects

Research

Musculoskeletal Alterations Team

Current Projects
Previous Projects

Integrated Endurance and Resistance Exercise Countermeasures Using a Gravity-Independent Training Device

Gregory R. Adams, Ph.D.

Calpains in Simulated Microgravity-Induced Muscle Atrophy

Parker B. Antin, Ph.D.

Pharmaceutical Countermeasure Effects on Tissue-Level Quality of Immobilized Bone (Postdoctoral Fellowship)

Devendra Bajaj, Ph.D.

Role of Muscle Loading on Mechanisms of Protein Translation and the Impact on Unloading-Induced Atrophy

Kenneth M. Baldwin, Ph.D.

Force Regulation as a Countermeasure to Muscle Atrophy

Kenneth M. Baldwin, Ph.D.

Space Radiation and Bone Loss: Lunar Outpost Mission-Critical Scenarios and Countermeasures

Ted A. Bateman, Ph.D.

Examination of Anti-Resorptive and Anabolic Treatments/Stimuli on Unloading-Induced Osteoporosis

Ted A. Bateman, Ph.D.

Maintaining Musculoskeletal Health in the Lunar Environment

Susan A. Bloomfield, Ph.D.

Bone Blood Flow During Simulated Microgravity: Physiological and Molecular Mechanisms

Susan A. Bloomfield, Ph.D.

Bone and Muscle Recovery from Simulated Microgravity

Susan A. Bloomfield, Ph.D.

Increasing the Efficiency of Exercise Countermeasures for Bone Loss

Susan A. Bloomfield, Ph.D.

Effect of Microgravity on Fracture Healing/Ultrasound as a Possible Countermeasure

Mark E. Bolander, M.D.

Hypergravity Resistance Training: Countermeasure to Microgravity

Vincent J. Caiozzo, Ph.D.

A Combinatorial Approach of Exercise and Myostatin Inhibition to Enhance Compromised Bone (Postdoctoral Fellowship)

Stephanie M. Carleton, Ph.D.

A Quantitative Test of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bedrest Analog

Peter R. Cavanagh, Ph.D., D.Sc.

Monitoring Bone Health by Daily Load Stimulus Measurement During Lunar Missions

Peter R. Cavanagh, Ph.D., D.Sc.

Foot Reaction Forces During Simulated ISS Exercise Countermeasures

Peter R. Cavanagh, Ph.D., D.Sc.

Cell and Molecular Biomechanics: Cardiac & Skeletal Muscle

P. Bryant Chase, Ph.D.

Cell and Molecular Biomechanics: Cardiac & Skeletal Muscle

P. Bryant Chase, Ph.D.

Integrated Regulation of Bone and Muscle Metabolism by Simulated Microgravity

Henry J. Donahue, Ph.D.

Molecular Signaling in Muscle Plasticity

Henry F. Epstein, M.D.

Pharmacological Inhibitors of the Proteosome in Atrophying Muscles (Also Kenneth Baldwin, Ph.D., UC Irvine, Effects of Unloading on Myosin Content and Isoform Specific Regulation in Skeletal Muscle)

Alfred L. Goldberg, Ph.D.

The Activation of Protein Breakdown in Muscle Upon Unloading and Possible Countermeasures

Alfred L. Goldberg, Ph.D.

The Activation of Protein Breakdown in Muscle Upon Unloading and Possible Countermeasures

Alfred L. Goldberg, Ph.D.

Genomics of Human Skeletal Muscle During Bed Rest and Exercise

Marc T. Hamilton, Ph.D.

Activity Dependent Signal Transduction in Skeletal Muscle

Susan L. Hamilton, Ph.D.

Enhancing the Efficacy of Musculoskeletal Countermeasures Using Computer Simulation (Postdoctoral Fellowship)

Andrea M. Hanson, Ph.D.

Therapeutic Modulation of Systemic Glucose-Dependent Insulinotropic Peptide Levels to Counteract Microgravity-Induced Bone Loss

Carlos M. Isales, M.D.

The Use of Aspirin and Other NSAIDs to Ameliorate Muscle Atropy Due to Simulated Weightlessness (Postdoctoral Fellowship)

Andrew Judge, Ph.D.

Gene Expression Profiling of Unloaded Skeletal Muscle

Susan C. Kandarian, Ph.D.

Leptin as a Regulator of Bone Formation in Microgravity

Gerard Karsenty, M.D., Ph.D.

Interaction Between IGF-1 and Integrin Signaling in the Response of Bone to Mechanical Load (Postdoctoral Fellowship)

Takuo Kubota, M.D., Ph.D.

Developing Novel,Targeted Countermeasures to Reduce Oxidative Stress and Skeletal Muscle Atrophy During Microgravity (First Award Fellowship)

James M. Kuczmarski, Ph.D.

Integrating Human Muscle Energetics and Mechanics

Martin J. Kushmerick, M.D., Ph.D.

Ultrasonic Assessment of Anisotropic Mechanical Properties of Cancellous Bone after Disuse with and without Anti-Resorptive Therapy (Postdoctoral Fellowship)

Luis Cardoso Landa, Ph.D.

An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions

Thomas F. Lang, Ph.D.

Whole Joint Health: Investigating Modeled Spaceflight Changes in Mice (First Award Fellowship)

Anthony G. Lau, Ph.D.

Recovery of IGF-1 Signaling in Bone by Skeletal Reloading (Postdoctoral Fellowship)

Roger Long, M.D.

Induction of Early Stages of Osteoarthritis After Exposure to Microgravity (First Award Fellowship)

Liliana Mellor, Ph.D.

Crosstalk Between Subchondral Bone and Articular Cartilage in Reduced Gravity May Contribute to Catastrophic Joint Damage (Career Advancement Award)

Liliana F. Mellor, Ph.D.

Effects of Simulated Weightlessness on the Repair of Lower-Limb Bone Fractures and on the Number of Bone-Derived Stem Cells

Ronald J. Midura, Ph.D.

Extent, Causes and Countermeasures of Impaired Fracture Healing in Hypogravity

Ronald J. Midura, Ph.D.

Motoneuron Influences on Muscle Atrophy in Simulated Microgravity Induced Muscle Atrophy

Dennis R. Mosier, M.D., Ph.D.

Novel Receptor-Based Countermeasures to Microgravity-Induced Bone Loss

Bert W. O'Malley, M.D.

Novel Receptor-Based Countermeasures to Microgravity-Induced Bone Loss

Bert W. O'Malley, M.D.

Bone Formation through Biomineralization and Bioengineering (Postdoctoral Fellowship)

Ronke M. Olabisi, Ph.D.

An Integrated Low-Volume Nutritional Countermeasure to Maintain Muscle Mass and Function During Space Exploration

Douglas Paddon-Jones, Ph.D.

Molecular Mechanisms that Impact Transcription of Myosin Genes in Human Skeletal Muscle in Response to Unloading: Role of Resistance Exercise (Postdoctoral Fellowship)

Clay E. Pandorf, Ph.D.

Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment

Lori Ploutz-Snyder, Ph.D.

Redox Modulation of Muscle Function in Microgravity

Michael B. Reid, Ph.D.

Redox Modulation of Skeletal Muscle Function in Microgravity

Michael B. Reid, Ph.D.

Molecular Mechanisms Regulating Muscle Fiber Composition Under Microgravity

Nadia A. Rosenthal, Ph.D.

A Biomechanical Countermeasure for Disuse Osteopenia

Clinton Rubin, Ph.D.

Skeletal Structural Consequences of Reduced Gravity Environments

Christopher B. Ruff, Ph.D.

Resorption Suppression and Bone Health in Disuse

Mitchell B. Schaffler, Ph.D.

Bone Recovery Potential after Bisphosphonate and PTH Treatment of Disuse Osteoporosis

Mitchell B. Schaffler, Ph.D.

The Effects of Partial Mechanical Loading and Ibandronate on Skeletal Tissues in the Adult Rat Hindquarter Suspension Model for Microgravity

Lester W. Schultheis, M.D.

GH/IGF-I Transgene Expression on Muscle Homeostasis

Robert J. Schwartz, Ph.D.

Defining and Preventing Bone Loss: A Microgravity Model

Jay R. Shapiro, M.D.

In Vivo Stress-Strain Dynamics in Human Muscle

Shantanu Sinha, Ph.D.

Receptor Countermeasures to Bone Loss in Microgravity

Carolyn L. Smith, Ph.D.

Receptor Countermeasures to Bone Loss in Microgravity

Carolyn L. Smith, Ph.D.

Effects of Abnormal Loading on Tibiofemoral Articular Cartilage Composition (Postdoctoral Fellowship)

Richard B. Souza, Ph.D.

Role of LINC complex in Maintenance of MSC ßcatenin Signaling Under Microgravity (First Award Fellowship)

Gunes Uzer, Ph.D.

Contribution of the Vestibular and Sympathetic Nervous Systems to Space-Induced Bone Loss (Postdoctoral Fellowship)

Guillaume Vignaux, Ph.D.

Assessment of Structural and Functional Knee Joint Degradation During Modeled Spaceflight

Jeffrey S. Willey, Ph.D.

Radiation Effects on Bone Tissue and Cells in Reduced Gravity (Postdoctoral Fellowship)

Jeffrey S. Willey, Ph.D.

Ca⁺² Homeostatis and Muscle Phenotype: Role of Cellular Energetics

Robert W. Wiseman, Ph.D.

Ca+2 Homeostatis and Muscle Phenotype: Role of Cellular Energetics

Robert W. Wiseman, Ph.D.

Prevention of Microgravity-Induced Stone Risk by KMgCitrate

Joseph E. Zerwekh, Ph.D.